Autonomous Vehicles and the Ethical Tension Between Occupant and Non-Occupant Safety

Autonomous vehicle manufacturers, people inside an autonomous vehicle (occupants), and people outside the vehicle (non-occupants) are among the distinct stakeholders when addressing ethical issues inherent in systems that include autonomous vehicles. As responses to recent tragic cases illustrate, advocates for autonomous vehicles tend to focus on occupant safety, sometimes to the exclusion of non-occupant safety. Thus, we aim to examine ethical issues associated with non-occupant safety, including pedestrians, bicyclists, motorcyclists, and riders of motorized scooters. We also explore the ethical implications of technical and policy ideas that some might propose to improve non-occupant safety. In addition, if safety (writ large) is truly the paramount priority for autonomous vehicle advocates, we contend that autonomous public transportation should be considered as a more effective and less expensive way to improve public safety

Ethical Issues in Open Source Software

In this essay we argue that the current social and ethical structure in the Open Source Software (OSS) Community stem from its roots in academia. The individual developers experience a level of autonomy similar to that of a faculty member. Furthermore, we assert that the Open Source Software Community\u27s social structure demands benevolent leadership. We argue that it is difficult to pass off low quality open source software as high quality software and that the Open Source development model offers strong accountability. Finally, we argue that Open Source Software introduces ethical challenges for universities and the software development community

On Using Model For Downstream Responsibility

The authors identify features of software and the software development process that may contribute to the differences in the level of responsibility assigned to the software developers when they make their software available for others to use as a tool in building a second piece of software. They call this second use of the software downstream use

On the Responsibility for Uses of Downstream Software

In this paper we explore an issue that is different from whether developers are responsible for the direct impact of the software they write. We examine, instead, in what ways, and to what degree, developers are responsible for the way their software is used “downstream.” We review some key scholarship analyzing responsibility in computing ethics, including some recent work by Floridi. We use an adaptation of a mechanism developed by Floridi to argue that there are features of software that can be used as guides to better distinguish situations where a software developer might share in responsibility for the software’s downstream use from those in which the software developer likely does not share in that responsibility. We identify five such features and argue how they are useful in the model of responsibility that we develop. The features are: closeness to the hardware, risk, sensitivity of data, degree of control over or knowledge of the future population of users, and the nature of the software (general vs. special purpose)

When AI Moves Downstream

After computing professionals design, develop, and deploy software, what is their responsibility for subsequent uses of that software “downstream” by others? Furthermore, does it matter ethically if the software in question is considered to be artificial intelligent (AI)? The authors have previously developed a model to explore downstream accountability, called the Software Responsibility Attribution System (SRAS). In this paper, we explore three recent publications relevant to downstream accountability, and focus particularly on examples of AI software. Based on our understanding of the three papers, we suggest refinements of SRAS

Reducing in-stent restenosis therapeutic manipulation of miRNA in vascular remodeling and inflammation

Background: Drug-eluting stents reduce the incidence of in-stent restenosis, but they result in delayed arterial healing and are associated with a chronic inflammatory response and hypersensitivity reactions. Identifying novel interventions to enhance wound healing and reduce the inflammatory response may improve long-term clinical outcomes. Micro–ribonucleic acids (miRNAs) are noncoding small ribonucleic acids that play a prominent role in the initiation and resolution of inflammation after vascular injury.<p></p> Objectives: This study sought to identify miRNA regulation and function after implantation of bare-metal and drug-eluting stents.<p></p> Methods: Pig, mouse, and in vitro models were used to investigate the role of miRNA in in-stent restenosis.<p></p> Results: We documented a subset of inflammatory miRNAs activated after stenting in pigs, including the miR-21 stem loop miRNAs. Genetic ablation of the miR-21 stem loop attenuated neointimal formation in mice post-stenting. This occurred via enhanced levels of anti-inflammatory M2 macrophages coupled with an impaired sensitivity of smooth muscle cells to respond to vascular activation.<p></p> Conclusions: MiR-21 plays a prominent role in promoting vascular inflammation and remodeling after stent injury. MiRNA-mediated modulation of the inflammatory response post-stenting may have therapeutic potential to accelerate wound healing and enhance the clinical efficacy of stenting

A design methodology for portable software on parallel computers

This final report for research that was supported by grant number NAG-1-995 documents our progress in addressing two difficulties in parallel programming. The first difficulty is developing software that will execute quickly on a parallel computer. The second difficulty is transporting software between dissimilar parallel computers. In general, we expect that more hardware-specific information will be included in software designs for parallel computers than in designs for sequential computers. This inclusion is an instance of portability being sacrificed for high performance. New parallel computers are being introduced frequently. Trying to keep one's software on the current high performance hardware, a software developer almost continually faces yet another expensive software transportation. The problem of the proposed research is to create a design methodology that helps designers to more precisely control both portability and hardware-specific programming details. The proposed research emphasizes programming for scientific applications. We completed our study of the parallelizability of a subsystem of the NASA Earth Radiation Budget Experiment (ERBE) data processing system. This work is summarized in section two. A more detailed description is provided in Appendix A ('Programming Practices to Support Eventual Parallelism'). Mr. Chrisman, a graduate student, wrote and successfully defended a Ph.D. dissertation proposal which describes our research associated with the issues of software portability and high performance. The list of research tasks are specified in the proposal. The proposal 'A Design Methodology for Portable Software on Parallel Computers' is summarized in section three and is provided in its entirety in Appendix B. We are currently studying a proposed subsystem of the NASA Clouds and the Earth's Radiant Energy System (CERES) data processing system. This software is the proof-of-concept for the Ph.D. dissertation. We have implemented and measured the performance of a portion of this subsystem on the Intel iPSC/2 parallel computer. These results are provided in section four. Our future work is summarized in section five, our acknowledgements are stated in section six, and references for published papers associated with NAG-1-995 are provided in section seven

MACE II - A Space Shuttle experiment for investigating adaptive control of flexible spacecraft

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76987/1/AIAA-1998-4319-483.pd

Quantitative sensory testing in children with sickle cell disease: additional insights and future possibilities.

Quantitative sensory testing (QST) is used in a variety of pain disorders to characterize pain and predict prognosis and response to specific therapies. In this study, we aimed to confirm results in the literature documenting altered QST thresholds in sickle cell disease (SCD) and assess the test-retest reliability of results over time. Fifty-seven SCD and 60 control subjects aged 8-20 years underwent heat and cold detection and pain threshold testing using a Medoc TSAII. Participants were tested at baseline and 3 months; SCD subjects were additionally tested at 6 months. An important facet of our study was the development and use of a novel QST modelling approach, allowing us to model all data together across modalities. We have not demonstrated significant differences in thermal thresholds between subjects with SCD and controls. Thermal thresholds were consistent over a 3- to 6-month period. Subjects on whom hydroxycarbamide (HC) was initiated shortly before or after baseline testing (new HC users) exhibited progressive decreases in thermal sensitivity from baseline to 6 months, suggesting that thermal testing may be sensitive to effective therapy to prevent vasoocclusive pain. These findings inform the use of QST as an endpoint in the evaluation of preventative pain therapies

An hypothesis to explain the ultrafiltration characteristics of peritoneal dialysis

Net removal of fluid and sodium from the body during peritoneal dialysis is accomplished with dialysis solutions that contain high glucose concentrations and are hyperosmolar to body fluid [1]. Commercially available peritoneal dialysis solutions contain glucose concentrations ranging from 1.5 to 4.25 g/dl and have osmolalities ranging from 334 to 490 mOsm/kg H2O. The solutions also contain concentrations of sodium, chloride, magnesium, and calcium that approach those of normal extracellular fluid. Acetate or lactate, rather than bicarbonate, is used as the nonchloride anion. Potassium may be added or, depending on the need for potassium removal, solutions may be potassium-free